Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae

Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae

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We report a case of a 63-year-old female patient who developed a Bike Parts - Fork Parts recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp).In the initial two rounds of phage therapy, phage resistant mutants developed within days.Although ERKp strains were completely resistant to sulfamethoxazole-trimethoprim, the combination of sulfamethoxazole-trimethoprim with the phage cocktail inhibited the emergence of phage resistant mutant in vitro, and the UTI of patient was successfully cured by this combination.Thus, we propose that non-active antibiotic and bacteriophage synergism (NABS) might be an alternative strategy in Creatine personalized phage therapy.